Research Interests:

My interests are multidisciplinary in that they encompass both research and regulatory affairs. My research interests include the bio effects of ionizing and non-ionizing (including ultrasound) radiation energy as a function of their physical characteristics.

At the same time I have maintained an interest in those areas of regulatory oversight of selected industries under the purview of the U.S. Food and Drug Administration (USFDA). Of particular consultative interests to me are the USFDA regulations which govern the current good manufacturing practices (i.e. CGMPs) of the industries involved in medical devices, biotechnology, institutional review boards (IRBs) and lasers. In addition to the foregoing over the last several years I have led joint efforts to formulate biotechnology research projects including UCLA, the USFDA, and the private sector. These efforts gave dealt with research projects in breast cancer diagnosis and treatment (currently at the West LA VA Medical Center), the application of Fourier Transform Infra-red (FTIR) spectroscopy to characterization of mammalian cells, chromosomes, neoplastic tissue, and selected polymers. The ultimate conclusion to these efforts is the formation of a Cooperative Research and Development Agreement (CRADA) under the auspices of the Federal Technology Transfer Act of 1987.

Papers and Publications:


Peer Reviewed Publications:

1. Roseboro, J.A.: “A Study of Alternatives to Chemical Fumigation in Mediterranean Fruit-Fly (Drosophila Melanogaster as Model) Disinfection,” JPL Publication (81-Series), August 1981.
   
2. Gammel, P.M.: Heyser, R.C.; Le Crosissette, D.H.; Roseboro, J.A.; and Wilkson, R.L.: “The Temperature and Frequency Dependence of Ultrasonic Attenuation in Liver,” Reflections, June 1981.
   
3. Roseboro, J.A.; Buchanan, P.; Norman, A.; and Stern, R.: “Effect of Ultrasonic Irradiation on Mammalian Cells and Chromosomes, in-vitro,” Physics in Medicine and Biology, v23, no. 2, pp 324-31, March 1978.
   
4. Coover, S.R.; Roseboro, J.A.; and Watson, J.E.: “Electric Charger for Pocket Ion Chamber Dosimeters,” Health Physics, v33, no. 5, pp 474-7, November 1977.
   
5. Roseboro, J.A.: “Ultrastructure of Hela Cells and Thoracic Duct Lymphocytes: Pre and Post – Ultrasonic Irradiation,” Ultrasound in Medicine, 3B, pp 2063-74, 1977.
   
6. Smokler, M.I.; Anselmo, V.; Frazier, R.; Le Croissette, D.; and Roseboro, J.A.: “Feasibility Study on the Design of a Probe for Rectal Cancer Detection,” JPL Publication (77-Series), May 1977.
   
7. Rollins, E.M.; Saylor, W.L.; and Roseboro, J.A.: “Dosimetry of Radium-226 Sources with the Fletcher-Suit Gynecological Applicator,” International Journal of Radiation Oncology, Biology and Physics, November 1976.
   
8. Roseboro, J.A.; Norman, A.; Machleder, H.J.; Paulus, H.; and Stern, R.: “The Therapeutic Efficacy of Ultrasound in Treatment of Autoimmune Disease,” Ultrasound in Medicine, 2: 487-500, 1976.
   
9. Gopala, Rao U.V.; Rollo, F.D.; and Roseboro, J.A.: “Tumor Dose-Rate Tables Instead of Central Axis Depth Dose Data and Tumor-Air-Ratios,” British Journal of Radiology, 40: 783, 1967.
   
10. Roseboro, J.A.; and Brill, Warren: “Report on Battelle N.W. Laboratory ---S.W. Radiological Health Laboratory Alaskan Caribou Muscle Cesium-137 Discrepancies,” Radiological Health Data, 1965